PODOPHYLLIC ACID LACTONE
Podophyllotoxin
CAS: 4354-76-1;518-28-5
Molecular Formula: C22H22O8
PODOPHYLLIC ACID LACTONE - Names and Identifiers
| Name | Podophyllotoxin |
| Synonyms | Podofilox Podophyllotoxin PODOPHYLLOTOXIN(P) Podophyllotoxin CRS PODOPHYLLIC ACID LACTONE 1,3,3a,4,9,9a-hexahydro-9-hydroxy-6,7-(methylenedioxy)-4-(3',4',5'-trimethoxyphenyl)benz[f]isobenzofuran-3-one |
| CAS | 4354-76-1 518-28-5 |
| EINECS | 208-250-4 |
| InChI | InChI=1/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1 |
PODOPHYLLIC ACID LACTONE - Physico-chemical Properties
| Molecular Formula | C22H22O8 |
| Molar Mass | 414.41 |
| Density | 1.370 |
| Melting Point | 183-184°C(lit.) |
| Boling Point | 597.9±50.0 °C(Predicted) |
| Specific Rotation(α) | -110.7 o (C=1, CHCL3) |
| Flash Point | 210.2°C |
| Solubility | Soluble in chloroform, acetone, ethyl acetate and benzene, soluble in ethanol, ether, insoluble in water. |
| Vapor Presure | 3.82E-15mmHg at 25°C |
| Appearance | White needle crystalline powder |
| pKa | 13.26±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.605 |
| MDL | MFCD00075290 |
| Use | Mainly used for condyloma acuminatum, can also be used for other viral warts |
PODOPHYLLIC ACID LACTONE - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R21 - Harmful in contact with skin R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | LV2500000 |
| FLUKA BRAND F CODES | 1-8-10 |
PODOPHYLLIC ACID LACTONE - Reference
| Reference Show more | 1. Wang Ping, Chen Tao, Liu Yongling, et al. Optimization of hot reflux extraction process of podophyllotoxin from peach tree by response surface methodology [J]. Chinese herbal medicine 2012 35(011):1864-1867. 2. Shan Jinfeng, Liu Ningzhi, du Xinyun, etc. Study on the extraction process of effective components of podophyllolicorice compatibility [J]. Modern chemical engineering, 2016(12):47-50. 3. Dong Yupeng, Sun Ping, Li Yongcai, Bi Yang, Zhang Miao, Huang Yi, Zhang Tingting. Antibacterial effect and mechanism of trans-2-hexenal on pear fruit spot pathogen Alternaria alternata [J]. Food Science, 2020, 41(07): -197. 4. Fan Sufang, Ma Junmei, Liu Min, et al. Determination of 15 toxic alkaloids in foods by high performance liquid chromatography-tandem mass spectrometry [J]. Food Science, 2018, 39(22):290-295. 5. Zi, Cheng-Ting, et al. "Synthesis and antioxidant Activity of 4 β-Triazole-podophyllotoxin Glycosides." Natural products and bioprospecting 5.2 (2015): 83-90. 6. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 7. [IF=3.641] Cheng-Ting Zi et al."Synthesis and antitumor activity of novel per-butyrylated glycosides of podophyllotoxin and its derivatives."Bioorgan Med Chem. 2015 Apr;23:1437 8. [IF=5.221] Zi Cheng-Ting et al."Design Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents."Front Chem. 2019 Jun;0:434 9. [IF=4.384] Xiu Zhao et al."Preparation, characterization and biological evaluation of β-cyclodextrin-biotin conjugate based podophyllotoxin complex."Eur J Pharm Sci. 2021 May;160:105745 |
PODOPHYLLIC ACID LACTONE - Reference Information
| use | mainly used for condyloma acuminatum, but also for other viral warts |
Last Update：2024-04-09 22:01:19
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Product Name: Podophyllotoxin Visit Supplier Webpage Request for quotationCAS: 518-28-5
Tel: 0714-3999186
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Mobile: 86+15671228036
QQ: 2853786052
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Multiple SpecificationsSpot supply
Product Name: Podophyllotoxin Visit Supplier Webpage Request for quotationCAS: 518-28-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Sulforaphane (SFN) Visit Supplier Webpage Request for quotationCAS: 142825-10-3
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402
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